2 edition of Some effects of glucagon and insulin in normothermic and hypothermic rats. found in the catalog.
Some effects of glucagon and insulin in normothermic and hypothermic rats.
Anne Louise Haxton Crawford
Written in English
|Contributions||Toronto, Ont. University.|
|LC Classifications||LE3 T525 MA 1963 C73|
|The Physical Object|
|Number of Pages||96|
Sasaki Y, Takahashi H, Aso H, Ohneda A, Weekes TE. Effects of cold exposure on insulin and glucagon secretion in sheep. Endocrinology. ; – doi: /endo Helman A, Gilbert M, Pfister-Lemaire N, Reach G, Assan R. Glucagon and insulin secretion and their biological activities in hypothermic rats. Hypothermic perfusion was the first to be translated to clinical organ preservation as it comes with minimal risks when the machinery malfunctions and has shown promising results for kidney preservation 16 and pilot studies in the li The risk of accidental warm ischemia has led to a cautious approach to normothermic perfusion.
Hypothermia and cardiopulmonary bypass. Effects of hypothermia on biochemical reactions. The Q 10 for chemical reactions is a measure of changes in rate of reaction for 10°C rise in temperature. For human tissues, Q 10 is approximately 2. That is, for each 10°C decrease in body temperature, the rate of reaction (i.e., metabolic rate or oxygen. Beyond the reported possible adverse events monitored in the two clinical trials, some metabolic perturbations might occur while patients are undergoing hypothermic therapy and rewarming to normothermic range. Hypothermia has been associated with hypokalemia, metabolic acido-sis, and hyperglycemia (70).
The effect of glucagon-like peptide-1 on energy expenditure and substrate metabolism in humans. Int J obesity. ; 24 (3)– doi: / Meier JJ, Gallwitz B, Schmidt WE, Nauck MA. Glucagon-like peptide 1 as a regulator of food intake and body weight: therapeutic perspectives. Eur J Pharmacol. Concentrations of glucose, insulin, and glucagon are higher during normothermic than hypothermic CPB. Nagaoka et al. (50) compared pulsatile with nonpulsatile perfusion in patients undergoing cardiac surgery with moderate hypothermia (body temperature approximately 26°C).
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When units insulin/kg was injected there was very little hypoglycaemic effect in normothermic rats, but in hypothermic rats (25 °C) a hypoglycaemic effect similar to that obtained with Propranolol administration had no effect in normothermic rats and did not affect the decrease in renal blood flow during hypothermia.
Fig. blood flow in normothermic and hypothermic (28°C) rats pretreated with an intravenous injection of saline, atropine, hexamethonium, propranolol, or yohimbine or with surgical subdiaphragmatic by: 1. Serum insulin was depressed during hypothermic induction (from 48 ± 4 in controls to 19 ± 3 μU/ml in hypothermic rats) and increased only slightly during the arousal process, remaining significantly lower than in normothermic by: Rat liver membranes were prepared from control, normothermic rats (Tr = +/- degrees C) and hypothermic rats (Tr = +/- degrees C) and purified according to Havrankowa.
The effects of two [D-Cys14]-analogues of somatostatin on basal plasma levels of glucagon, insulin and glucose were determined in unanaesthetized rats to re-examine a glucagon-selective action of. Ball, E. G., and R. Jungas: Some effects of hormones on the metabolism of adipose tissue.
Recent Progr. The effect of glucagon on blood sugar and inorganic phosphorus levels in normothermic and hypothermic rats.
Canad. Physiol. Pharmacol. 43 The effect of insulin, glucagon and prolactin on lipid synthesis and related metabolic. Helman A, Gilbert M, Pfister-Lemaire N, Reach G, Assan R: Glucagon and insulin secretion and their biological activities in hypothermic rats.
Endocrinology. /endo CAS Article PubMed Google Scholar. The membranes were prepared from control, normothermic rats (Tr = ± °C) and hypothermic rats (Tr = ± °C) and purified according to the method described by Havrankowa. In order. The slight increase in glucose and triglycide levels may reflect raised glucagon levels in arterial plasma.
The Changes in metabolite profile in conscious hypothermie rats hypothermia-induction time was too short to give rise to an intolerance to glucagon effects, according to the previous study by Hoo-Paris et al.
Brown adipose tissue (BAT) thermogenesis is a conserved mechanism to maintain body temperature in mammals. However, since BAT contribution to energy expenditure can represent a relevant modulator of metabolic homeostasis, many studies have focused on the nervous system and endocrine factors that control the activity of this tissue.
There is long-established evidence. There is considerable evidence that some or all of these effects may be due to a direct central action of glucose, 2-DG, insulin, and glucagon on brain mechanisms concerned with the regulation of hunger and satiety although influences on peripheral “glucoreceptors” have been demonstrated as well.
Intraperitoneal or central injection of 3-T(1)AM or T(0)AM into mice, rats, or Djungarian hamsters caused various prompt effects, such as metabolic depression, hypothermia.
To examine the effect of treatment with liraglutide, hPrRP31 or palm PrRP31 on tau phosphorylation, the SH-SY5Y cells were incubated with the compounds in normothermic (37°C) or hypothermic (30°C) conditions for 2 h and cell lysates were analyzed by immunoblots (n = 2– 3, two independent experiments).
The effects of prolonged hypothermic ischemia and subsequent normothermic perfusion on the energetic metabolism and intracellular pH (pH in) of isolated rat livers were studied by phosphorus nuclear magnetic resonance side triphosphate (NTP) depletion and intracellular pH were studied within an h-storage phase, by using the.
Metabolic and endocrine effects. For each decrease in core temperature by 1 °C, the basal and cerebral metabolic rates decrease by 5 to 7%, leading to decreased glucose utilization.
40 Hypothermia has been associated with hyperglycemia in adult animal and human studies as a result of decreased utilization, decreased insulin release and sensitivity, and increased.
Glucagon and insulin secretion and their biological activities in hypothermic rats. Endocrinology ; (5): – CAS. These results seem to indicate that hypothermia, a sti mulatory effector of non-shivering thermogenesis in the newborn rat at birth, results in a further increase of the brown fat CPT1 activity as compared with those from normothermic starved newborn rats.
Then, the no brown fat by hypothermia may decreases the raas suggested in (16) and increa. WE insulin levels were approximately fold higher than what was observed in fed rats, and without glucagon supplementation.
Briefly, in MFA the change in the concentration of intracellular metabolites is assumed to be zero (pseudo steady-state assumption) hence the sum of fluxes of each metabolite's uptake, synthesis and utilization equals.
Abstract. Glucagon is a polypeptide hormone secreted by the α 2-cells of the pancreas in response to a variety of hormone exhibits many biologic effects in several different target organs, but it is best known for its role in the homeostatic control of blood glucose.
Fig. 2 - Means of plasma insulin and glucagon in non-diabetic control rats (NC) and pancreas transplanted rats (PT) seven days prior (M0) and 1, 3, 6. Currently, there are 3 variants of liver machine perfusion that are distinguished by the perfusate temperature: hypothermic, subnormothermic, and normothermic.
Although studies have shown the superiority of oxygenated perfusion over standard cold storage, each of these variants has its advantages and disadvantages.Loubatieres-Mariani MM, Chapal J, Puech R, Lignon F, Valette G () Different effects of hypothermia on insulin and glucagon secretion from the isolated perfused rat pancreas.
Diabetologia – PubMed Google Scholar.The trend of faster recovery in hypothermic animals compared with normothermic animals (without seizures) may be due to an anti-edema effect of hypothermia.
Posttraumatic (37) or intraischemic (